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JACS: New Application of Chiral Bisoxazoline Ligands — Xiaohong Huo & Wanbin Zhang Group, Shanghai Jiao Tong University
JACS: New Application of Chiral Bisoxazoline Ligands — Xiaohong Huo & Wanbin Zhang Group, Shanghai Jiao Tong UniversityResearch Background γ-Functionalized primary alcohols are widely found in natural products and drug molecules. Extensive studies have focused on α- and β-functionalization of primary alcohols. However, γ-position transformation remains a formidable s
Updated on 11.05
CCS Chemistry | New Application of BINOL-Derived Chiral Phosphoramidite Ligands from Shu-Li You & Yuan-Zheng Cheng Group, SIOC
CCS Chemistry | New Application of BINOL-Derived Chiral Phosphoramidite Ligands from Shu-Li You & Yuan-Zheng Cheng Group, SIOCResearch Background Bicyclo[2.1.1]hexane (BCH) serves as a highly promising saturated bioisostere for meta-substituted benzene rings. Incorporation of BCH moieties into drug candidates increases the fraction of sp³-hybridized carbons, improves aq
Updated on 11.03
Good News! Professor Zhang Junliang Selected for the World's Top 2% Scientists 2026 Career‑long Impact List
Good News! Professor Zhang Junliang Selected for the World's Top 2% Scientists 2026 Career‑long Impact ListRecently, the team led by Professor John P. A. Ioannidis from Stanford University, the United States, in collaboration with Elsevier, has released the World's Top 2% Scientists 2026 list. Professor Zhang Junliang, Founder of our company, has been suc
Updated on 11.03
JACS: New Application of Sadphos Ligands in Pd-Catalyzed Asymmetric [3+3] Cycloaddition
JACS: New Application of Sadphos Ligands in Pd-Catalyzed Asymmetric [3+3] Cycloaddition1. English Official Version for Global Website Research Background Most palladium-catalyzed asymmetric cycloadditions employing aniline derivatives as 1,3-dipoles are limited to [3+2] cyclization to construct chiral indoline skeletons. Asymmetric [3+
Updated on 09.28
Sadphos Ligands: Four High‑Impact Publications Within One Month!
Sadphos Ligands: Four High‑Impact Publications Within One Month!1. English Official Version for Global Website Chiral ligands serve as fundamental tools for asymmetric catalysis. Sadphos ligands feature a highly modular backbone. The N‑aryl ring, phosphine substituents and sulfinamide N‑H site can be independentl
Updated on 09.02
Five Axially Chiral Ligand Kits Newly Released
Five Axially Chiral Ligand Kits Newly Released1.1 Axially Chiral Ligands: Core Catalytic Scaffolds for Asymmetric Synthesis Axially chiral ligands construct well‑defined chiral cavities via atropisomerism of binaphthyl and biphenyl backbones. They coordinate efficiently with noble metals includi
Updated on 08.21
Imidazole-Based N-Heterocyclic Carbene (NHC) Ligand Kit
Imidazole-Based N-Heterocyclic Carbene (NHC) Ligand Kit1.1 Background & Core Advantages of Imidazole NHC Ligands In 1991, American chemist Anthony J. Arduengo achieved the first stable isolation of free imidazole-type N-heterocyclic carbenes (NHCs), overturning the conventional view that carbenes only ex
Updated on 08.11
Pd-Catalyzed Asymmetric Dearomative Heck/Tsuji-Trost Difunctionalization of Naphthalenes
Pd-Catalyzed Asymmetric Dearomative Heck/Tsuji-Trost Difunctionalization of Naphthalenes1. English Official Research Introduction (Global Website Version) Aromatic compounds are abundant fundamental feedstocks in organic synthesis and medicinal chemistry. Driven by the modern drug design concept of escaping planar molecules , dearomati
Updated on 07.24
Photocatalytic Conversion of Aminocyclopropanes to γ‑Lactams by Sequential Ring-Expansion and Peripheral Diversification
Photocatalytic Conversion of Aminocyclopropanes to γ‑Lactams by Sequential Ring-Expansion and Peripheral Diversification 1. English Official Research Brief (Global Website Version) Cyclic frameworks are fundamental structural backbones of pharmaceuticals, agrochemicals and functional materials. Skeletal ring expansion serves as a powerful skeleton-editing strategy
Updated on 07.20
Cobalt-Catalyzed Migratory E-Selective Asymmetric Aza-Nozaki–Hiyama–Kishi Coupling
Cobalt-Catalyzed Migratory E-Selective Asymmetric Aza-Nozaki–Hiyama–Kishi CouplingPublication Information Journal: Angewandte Chemie International Edition Article Type: Hot Paper DOI: 10.1002/anie.8611979 Publication Year: 2026 Research Group: Prof. Shaolin Zhu & Dr. Yu Wang Group, Nanjing University Authors: Yi Wang, Yougui Luo, Lifu
Updated on 07.08
Metal Iridium Photocatalyst in Photodriven SmI2-Catalyzed Asymmetric Ketyl-Olefin Coupling
Metal Iridium Photocatalyst in Photodriven SmI2-Catalyzed Asymmetric Ketyl-Olefin CouplingResearch Background Samarium(II) iodide (SmI2) is an important single-electron reductant in organic synthesis, traditionally used in (super)stoichiometric amounts. Although catalytic applications have been achieved in recent years, catalytic asymme
Updated on 04.29
New Applications of Sadphos Ming-Phos Ligands
New Applications of Sadphos Ming-Phos LigandsResearch Background The chiral gem-diaryl motif is a core scaffold in numerous natural products and drug molecules. The γ,γ-diaryl carbonyl skeleton, in particular, plays a key role in the synthesis of pharmaceuticals such as integrin receptor inhibi
Updated on 04.08
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