Chiral phosphoric acids are important chiral Brønsted acid catalysts for asymmetric synthesis. They possess strong acidity and act as bifunctional catalysts, capable of controlling the stereoselectivity of reactions through fine structural adjustments. They can efficiently catalyze various asymmetric reactions, such as Friedel–Crafts reactions, Mannich reactions, asymmetric hydrogen transfer reactions, and cycloaddition reactions, exhibiting excellent stereoselectivity. The development of chiral phosphoric acids has provided a powerful means for the synthesis of chiral compounds, promoting the advancement of fields such as drug research and development.
To support relevant research, a chiral phosphoric acid kit containing 5 advantageous catalyst structures is specially launched this time. These catalysts have shown excellent catalytic activity and selectivity in certain reactions.