The Zhang Junliang research groupsuccessfully incorporated sterically hindered, electron-richdi-tert-butylphosphine ligands into their self-developed Sadphos scaffold,synthesizing a series of TY-Phos chiral ligands. These ligands exhibit simplestructures, ease of modification, and contain multiple soft/hard coordinationatoms, enabling flexible coordination with transition metals. Since their firstreport in 2020, TY-Phos ligands have demonstrated exceptional enantioselectiveinduction capabilities in various reactions, including palladium- andgold-catalyzed asymmetric three-component coupling, α-arylation of aldehydes,hydroarylation, and Heck/Tsuji-Trost reactions. They represent a highlypromising class of chiral ligands [1].

To support related research, we now offer a​TY-Phos Ligand Kit​ containing eight optimizedligands, all of which have shown outstanding catalytic activity and selectivityin specific reactions. Below are key application examples:

Achieved the first asymmetricfluoroarylation of difluoroolefins, enabling the synthesis of a series ofchiral trifluoromethyl compounds with high enantioselectivity [2].

Realized the first asymmetric arylation ofα,α-disubstituted linear aldehydes with aryl bromides, providing access tofunctionalized chiral quaternary α-aryl aldehydes [3].

Effectively modulated the chemoselectivity,regioselectivity, and enantioselectivity in reactions between substitutedo-bromophenols and 1,3-dienes, enabling efficient asymmetric synthesis of2-substituted 2,3-dihydrobenzofurans [4].