Axially chiral ligands construct well‑defined chiral cavities via atropisomerism of binaphthyl and biphenyl backbones. They coordinate efficiently with noble metals including Ru, Rh, Ir, Pd and Cu, and enable a broad scope of classic asymmetric transformations: asymmetric hydrogenation, asymmetric allylic substitution, Friedel‑Crafts addition, cyclopropanation, biaryl coupling, Lewis‑acid catalysis and more. These ligands are indispensable reagents for chiral drug substance manufacturing, complex heterocyclic intermediate preparation and synthetic methodology research.

Kaitailai Platinum (Anhui) has launched five standardized dedicated kits sorted by axial‑chiral backbone. Each series is independently packaged for immediate high‑throughput catalytic screening.

1. BINOL (Binaphthol) Ligand Screening KitThis kit contains 10 BINOL ligands with systematically varied electronic properties and steric hindrance. Structural variants include phenyl, polyfluoroaryl, trifluoromethyl‑substituted aryl, naphthalene‑fused and multi‑isopropyl alkyl‑modified backbones. It supports one‑stop ligand screening for chiral Lewis‑acid catalysis, asymmetric cycloaddition, carbonyl addition and synthesis of chiral phosphoric acid derivatives.

2. MOP Binaphthyl Monophosphine Ligand Screening KitThis kit includes six binaphthyl P,O‑type monophosphine ligands. Multiple oxygen‑containing side‑chains (methoxy, isopropoxy, benzyloxy, hydroxyl) are provided, together with two phosphine moieties: diphenylphosphine and dicyclohexylphosphine. High‑throughput screening can be readily performed for Pd‑, Cu‑ and Au‑catalyzed asymmetric allylation, biaryl construction and conjugate‑addition reactions.

3. BINAP Binaphthyl Bisphosphine Ligand Screening KitThree modified BINAP derivatives are supplied: electron‑rich methyl‑aryl phosphine, dicyclohexyl alkyl phosphine and bulky di‑tert‑butyl aryl phosphine structures. The kit facilitates steric‑effect screening for industrial‑relevant asymmetric hydrogenation of ketones, enamides and unsaturated carboxylic acids, as well as asymmetric C‑C cross‑coupling.

4. MeO‑BIPHEP Biphenyl Bisphosphine Ligand Screening KitTen MeO‑BIPHEP‑type biphenyl bisphosphine ligands are included. Variants cover electron‑withdrawing trifluoromethyl‑substituted aryls, electron‑rich tert‑butyl / methoxy‑substituted aryls, dimethylamino‑functionalized aromatics and chlorinated backbones. Electronic and steric parameters are finely tuned for process screening of asymmetric hydrogenation of diverse olefins and heterocyclic ketones.

5. TunePhos Tunable Bridged Bisphosphine Ligand Screening KitFive ether‑bridged conformation‑locked biphenyl bisphosphine ligands with different ring sizes are provided, featuring rigid scaffolds: five‑membered dioxolane, six‑membered dioxane, seven‑membered cyclic acetal and benzo‑dioxolane fused rings. The biaryl torsion dihedral angle is fixed by the bridge structure. The kit is suitable for high‑selectivity screening under high‑temperature / high‑pressure hydrogenation conditions for sterically hindered, difficult‑to‑reduce multi‑substituted substrates.

Kaitailai Platinum (Anhui) Co., Ltd. presents the full portfolio of axially chiral ligand kits. The five classic chiral backbones are fully covered with continuous gradients of steric and electronic effects. No in‑house synthesis or resolution is required. Customers can start high‑throughput asymmetric catalytic screening out‑of‑the‑box, greatly shortening R&D cycles for chiral pharmaceuticals and fine‑chemical process optimization. Global inquiries and cooperation are warmly welcomed.